In 2131 AD Deunan Knute has been a soldier on countless battlefields for most of her life. When the World War ends, she is transported to the city of Olympus to live peacefully and finds out that, in an effort to protect the human race from future wars, humans have created the Bioroids, a genetically enhanced race of people that have restrained feelings and therefore cannot hurt each other. She discovers, however, that not everyone is happy with this Human-Bioroid symbiosis: Many humans treat Bioroids as a lower species and as a threat to their future. The human-controlled military is seeking to annihilate all Bioroids, and the Bioroid-controlled government is afraid of a coup d'état.The task falls on Deunan to control the situation, and to avert the inter-species war. In this she is aided by her former lover, Briareos, who has lost his body in war, to become a cyborg — a brain in an artificial body.

Growing out of the chaos of a global war, the city of Utopia is populated by humans and bioroids (artificial humans). On the surface, everything is harmonious, but tensions lurk. Into this seemingly perfect society comes a survivor of the wars, Deunan Knute, who carries a legacy that will turn out to be of critical importance to the future of humanity.

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Appleseed takes place in the aftermath of World War III, where the General Management Control Office has constructed the experimental city known as Olympus. Built to be a paradise on Earth, Olympus is inhabited by humans, cyborgs, and bioroids (genetically engineered humans designed for increased physical capabilities and decreased emotional capabilities). Bioroids run and control all of the administrative functions of Olympus, ensuring that the city remains the utopian society it was meant to be for all of its citizens. But for some people living in Utopia, the city has become less of a home and more of a cage. Police officer Calon Mautholos has grown to despise Olympus following his wife's suicide, blaming her death on the lack of creative freedom caused by the rules binding the citizens of the city. As his hatred for the city grows, Calon conspires with the terrorist A.J. Sebastian to destroy the Legislature of the Central Management Bureau to send the rules of Olympus that killed his wife tumbling down. But when Calon discovers it is not political malcontent, but rather hatred for bioroids that motives Sebastian, Calon turns renegade and gains the attention of city officials. Deunan Knute and her partner Briareos of the ESWAT counter-terrorism unit are dispatched to hunt down and stop Calon and Sebastian... by any means necessary!

A young female soldier Deunan and her cyborg partner Briareos survive through the post World War 3 apocalyptic New York in search of human's future hope, the legendary city of Olympus.

Set in a different series of events, this story does not follow the previous Appleseed movie canon (despite being directed by the same director of the previous movies); it is an alternate story to their beginnings. Briareos is already a cyborg and did not become separated from Deunan to be later reunited in Olympus to join ESWAT. Appleseed Alpha depicts the early days of Deunan Knute and Briareos in the 22nd century, as they embark on a journey throughout dystopic ruins of New York in search of the city of Olympus. They are hired by Two Horns, the warlord of the ruined city, to eliminate bipedal combat machines. During the fight, they encounter Iris and Olson, both on a mission. Deunan and Briareos befriend them and decide to join their mission. Iris is tasked with preventing the malevolent cyborg Talos from capturing a secret weapon humans were building. Talos uses Iris to activate the gigantic war machine.

Deunan, a young female warrior, and Briareos, a veteran cyborg-soldier, are both partners and lovers. As members of E.S.W.A.T., the elite special forces serving Olympus, they are deployed whenever trouble strikes. The two fighters find their partnership tested in a new way by the arrival of a new member to their ranks—an experimental Bioroid named Tereus.

In the wake of the destruction of a worldwide non-nuclear war, the city Olympus has become the control center of the world. Run by Bioroids (cloned humans made from only the best DNA), it is defended from terrorists by special military forces. Among these are former LAPD SWAT member Deunan Knotts and her multipurpose cyborg partner Brialeos. They f… more In the wake of the destruction of a worldwide non-nuclear war, the city Olympus has become the control center of the world. Run by Bioroids (cloned humans made from only the best DNA), it is defended from terrorists by special military forces. Among these are former LAPD SWAT member Deunan Knotts and her multipurpose cyborg partner Brialeos. They face a challenge from the Human Liberation Front and its terrorist underbelly the Argonauts. The leader of this group, Al Ceides, supposedly died 20 years ago in an attack on Poseidon, but now his shadow emerges once again.

After facing massive destruction from a devastating war, the city Olympus has become the last stronghold as the center of command for the world. In order to protect the city from a group of terrorists known as the Argonauts, former LAPD SWAT member, Deunan Knotts, runs special military forces consisting of Biroids (cloned humans) and her cyborg partner Brialeos. Knotts must protect the city at all costs but is met with difficulties when Al Ceides, the Argonaut leader thought to be dead, resurfaces and causes problems.

In the wake of the destruction of a worldwide non-nuclear war, the city Olympus has become the control center of the world. Run by Bioroids (cloned humans made from only the best DNA), it is defended from terrorists by special military forces. Among these are former LAPD SWAT member Deunan Knotts and her multipurpose cyborg partner Brialeos. They face a challenge from the Human Liberation Front and its terrorist underbelly the Argonauts. The leader of this group, Al Ceides, supposedly died 20 years ago in an attack on Poseidon, but now his shadow emerges once again.

This is a remix, theatrical release of the first half of the Appleseed XIII series.

In the wake of the destruction of a worldwide non-nuclear war, the city Olympus has become the control center of the world. Run by Bioroids (cloned humans made from only the best DNA), it is defended from terrorists by special military forces. Among these are former LAPD SWAT member Deunan Knute and her multipurpose cyborg partner Briareos. They face a challenge from the Human Liberation Front and its terrorist underbelly the Argonauts. The leader of this group, Al Ceides, supposedly died 20 years ago in an attack on Poseidon, but now his shadow emerges once again.