10,000 years in the future, the world has become a very different place; monsters roam the land freely, and people, although equiped with high tech weapons and cybernetic horses, live a humble life more suited to centuries past. The story focuses on a small hamlet plagued by monster attacks and living under the shadow of rule by Count Magnus Lee, a powerful vampire lord who has ruled the land for thousands of years. When a young girl is bitten by the Count and chosen as his current plaything, she seeks out help of a quiet wandering stranger, D. It so happens that D is one of the world`s best vampire hunters, and he takes it upon himself to cut through Magnus Lee`s many minions, and put an end to the Count`s rule.

In the distant future...Vampires rule the night, but their numbers are dwindling. With huge bounties on their heads, a class of hunters has emerged, Bounty Hunters. One hunter is unlike all the others. He is a Dunpeal — a half human, half vampire. At war with himself, feared by all, tortured and alone, he is... Vampire Hunter D. — from introD, the infamous dunpeal outcast and renowned vampire hunter has fought for the grudging acceptance among humans through his prowess at hunting the creatures of the night. He is called upon to locate Charlotte Elbourne, the lovely daughter of an affluent family who apparently has been kidnapped by a powerful vampire named Meier Link.Charlotte's father offers a large bounty for her return, be she dead or alive, a task D willingly accepts, even with the notorious Marcus brothers Borgoff, Kyle, Nolt & Grove and their compatriot Leila, seeking the prize as well.As the sun sets, the hunt is on, but as the chase evolves it becomes more and more apparent that some sinister evil lurks in the shadows, secretly plotting and manipulating the hunters' every move. An insidious trap is set, and with the tables turned the hunters become the hunted!

The story revolves around D, the infamous "dunpeal" (born of a vampire father and a human mother) outcast and renowned vampire hunter. His prowess at hunting the creatures of the night allowing his acceptance among humans, he is called upon to locate Charlotte Elbourne, the lovely daughter of an affluent family who has been mysteriously kidnapped. When the sun sets, the hunt goes on! Charlotte`s father offers a rich bounty, be she dead or alive, a task D willingly accepts, even with notorious Markus brothers and their gang of bounty hunters seeking the prize as well. Amidst the chase and unknown to all lurks a sinister evil which has been secretly manipulating their every move and has set a chilling trap that none will expect and few will survive. With the tables turned and the secrets revealed, the hunters could quickly become the hunted!

It's been a long winter for mankind, overthrown from its place of dominance after being defeated in the great war against vampires. A small city-state protected by a massive wall of light has become one of the last strongholds of the human race -its leaders determined to regain control over the world they have lost. But within the oppressive city walls, young Momo dreams of a peaceful coexistence with humans' greatest foe. On the other side, vampire queen Fine, who once loved a human, has decided to desert the battlefield. Seen as betrayers by their own kind, the two have a fateful encounter during yet another savage battle. Together they start a journey in search of "Eden," an utopic garden of peace that old stories are whispering about, but no-one has ever seen...

It's been a long winter for mankind, overthrown from its place of dominance after being defeated in the great war against vampires. A small city-state protected by a massive wall of light has become one of the last strongholds of the human race -its leaders determined to regain control over the world they have lost. But within the oppressive city walls, young Momo dreams of a peaceful coexistence with humans' greatest foe. On the other side, vampire queen Fine, who once loved a human, has decided to desert the battlefield. Seen as betrayers by their own kind, the two have a fateful encounter during yet another savage battle. Together they start a journey in search of "Eden," an utopic garden of peace that old stories are whispering about, but no-one has ever seen...

Yuki’s earliest memory is of a stormy night in winter, wherein she was attacked by a vampire… And then rescued by another. Now 10 years later, Yuki Cross, the adopted daughter of the headmaster of Cross Academy, has grown up and become a guardian of the vampire race, protecting her savior, Kaname, from discovery as he leads a group of vampires at the elite boarding school. But also at her side is Zero Kiryu, a childhood friend who’s hatred for the creatures that destroyed everything he held dear, is now determined never to trust them. This coexisting arrangement seems all well and good, but have the vampires truly renounced their murderous ways, or is there a darker truth behind their actions? Is Kaname’s infatuation with Yuki the beginning of a forbidden romance, or is it something in her forgotten past that draws him to her? In this world of secrets, nothing is as it seems, and the price of misplaced trust may even be worse than death.

Cross Academy is an elite boarding school with two separate, isolated classes: the Day Class and the Night Class. On the surface, Yuuki Cross and Zero Kiryuu are prefects of the academy, and attempt to keep order between the students as classes rotate in the evenings. As the night class is full of utterly gorgeous elites, this can sometimes prove to be a bit difficult. It is completely necessary, however, as those "elites" are actually vampires. Yuuki and Zero act as guardians, protecting the secrets of the Night Class and the safety of the ignorant day class. As the adopted daughter of the academy's chairman, Yuuki takes her job with a serious and energetic attitude. It also allows her to interact with her secret crush and savior, the night class' dorm president, Kaname Kuran. Zero, on the other hand, has a deep-rooted hatred against vampires, and at times, does not hesitate to kill. Can vampires and humans co-exist, even in the strict setup of the Cross Academy? Only time will tell.

Yuuki wants to know more about her true family and her forgotten past and starts a research. The secret will be revealed. Yuki, Kaname and Zero will show the begining of a new mystery and a forbidden love.

As a direct continuation of the first season, Zero comes back after his disappearance from the academy. Despite her relief, Yuuki, whose past is still shrouded in mystery, wonders what exactly happened to Zero during the separation. As Zero continues having the strange vision that appeared since the day he drank Kaname's blood, he visits the now awakened Maria Kurenai in an attempt to find answers. She only provides him with a cryptic answer that suggests who the true enemy really might be. In the meantime, vampires from the Supreme Vampire Council arrive at the academy in order to punish Zero with death for his sin of killing a pureblood. However, Kaname intervenes with the council's decision with not only the intention of saving Zero but with another purpose unbeknown to everyone around him.

Evil Shinma (shape-shifting monsters and vampires) roam the Earth on a mission to unleash their darkness upon the Human race. Miyu Royal Princess from the dark is the Chosen One—the one being who must banish the Evil Shinma from the Earth. She has the power to offer Humans the gift of eternal happiness, yet is herself, trapped between two worlds; destined for perpetual solitude and internal conflict. Miyu's only companion is Larva, once an evil Shimna; now her devoted guardian. Together they share a dark journey through the weakness of the human heart and the tragic loss of innocence. Cut off from humanity by the knowledge of what she is, Miyu lives an endless quest as both the hunter and the hunted, on the edge of darkness.

Evil Shinma (shape-shifting monsters and vampires) roam the Earth on a mission to unleash their darkness upon the Human race. Miyu Royal Princess from the dark is the Chosen One—the one being who must banish the Evil Shinma from the Earth. She has the power to offer Humans the gift of eternal happiness, yet is herself, trapped between two worlds; destined for perpetual solitude and internal conflict. Miyu's only companion is Larva, once an evil Shimna; now her devoted guardian. Together they share a dark journey through the weakness of the human heart and the tragic loss of innocence. Cut off from humanity by the knowledge of what she is, Miyu lives an endless quest as both the hunter and the hunted, on the edge of darkness.

A quiet gothic horror story about a vampire girl, Miyu, whose destiny it is to hunt down murderous demons known as Shinma and return them to their land of origin, the Dark. Miyu is pursued by the Spiritualist Himiko, determined to find out who Miyu is and to stop her from sucking the life blood from helpless humans. Each of the four episodes chronicle one of Miyu's encounters with a Shinma and the humans that it is affecting, from the perspective of Himiko's pursuit of Miyu.